Nitric oxide donors for treating preterm labour
نویسندگان
چکیده
منابع مشابه
Nitric oxide donors: novel cancer therapeutics (review).
The development of cancer cell resistance to various cytotoxic stimuli continues to be a major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric oxide (NO) is emerging as a potential anti-oncogenic agent to overcome tumor cell resistance to conventional therapeutic agents. NO is a ubiquitous, water-soluble, free radical gas that exerts a wide range of biological...
متن کاملDual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour.
BACKGROUND AND PURPOSE Maternal infections are one of the main causes of adverse developmental outcomes including embryonic resorption and preterm labour. In this study a mouse model of inflammation-associated preterm delivery was developed, and used to study the relationship between nitric oxide (NO) and prostaglandins (PGs). EXPERIMENTAL APPROACH The murine model of preterm labour was achie...
متن کاملInhaled nitric oxide in preterm infants.
OBJECTIVES To systematically review the evidence on the use of inhaled nitric oxide (iNO) in preterm infants born at or before 34 weeks gestation age who receive respiratory support. DATA SOURCES We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Studies (CENTRAL) and PsycInfo in June 2010. We also searched the proceedings of the 2009 and 2010 Pediatric Academic Societie...
متن کاملInhaled nitric oxide for respiratory failure in preterm infants.
BACKGROUND Inhaled nitric oxide (iNO) is effective in term infants with hypoxic respiratory failure. The pathophysiology of respiratory failure and the potential risks of iNO differ substantially in preterm infants, necessitating study in this population. OBJECTIVES To determine the effect of treatment with iNO on death, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and...
متن کاملInhaled nitric oxide for the preterm infant: evidence versus practice.
In the current issue of the journal, Ellsworth et al report a small but significant increase (from 5.0% to 6.2%) in the off-label use of inhaled nitric oxide (iNO) between 2009 and 2013 in preterm infants born earlier than 30 weeks. This increase occurred in spite of the publication of the iNO Consensus Statement in 2011 and the 2014 report from the American Academy of Pediatrics. Both reports ...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2014
ISSN: 1465-1858
DOI: 10.1002/14651858.cd002860.pub2